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selected publications


Cell (2022)

Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome.

Fengbin Wang, Virginija Cvirkaite-Krupovic, Matthijn Vos, Leticia C Beltran, Mark AB Kreutzberger, Jean-Marie Winter, Zhangli Su, Jun Liu, Stefan Schouten, Mart Krupovic, Edward H Egelman


JACS (2022)

Enzyme Responsive Rigid-Rod Aromatics Target “Undruggable” Phosphatases to Kill Cancer Cells in a Mimetic Bone Microenvironment

Meihui Yi, Fengbin Wang, Weiyi Tan, Jer-Tsong Hsieh, Edward H. Egelman, and Bing Xu


Chem. Rev. (2022)

Cryo-EM of Helical Polymers

Fengbin Wang, Ordy Gnewou, Armin Solemanifar, Vincent P Conticello, Edward H Egelman


Nat. Microbio. (2022)

Cryo-EM structure of an extracellular Geobacter OmcE cytochrome filament reveals tetrahaem packing

Fengbin Wang, Khawla Mustafa, Victor Suciu Zhangli Su, Dong Si, Allon I. Hochbaum, Edward H. Egelman and Daniel R. Bond


PNAS (2022)

Archaeal bundling pili of Pyrobaculum calidifontis reveal similarities between archaeal and bacterial biofilms

Fengbin Wang, Virginija Cvirkaite-Krupovic, Mart Krupovic, and Edward H. Egelmana


BPJ (2022)

DeepTracer ID: De Novo Protein Identification from Cryo-EM Maps

Luca Chang, Fengbin Wang, Kiernan Connolly, Hanze Meng, Zhangli Su, Virginija Cvirkaite-Krupovic, Mart Krupovic, Edward H. Egelman, Dong Si


Matter (2021)

Deterministic chaos in the self-assembly of β sheet nanotubes from an amphipathic oligopeptide

Fengbin Wang, Ordy Gnewou, Shengyuan Wang, Tomasz Osinski, Xiaobing Zuo, Edward H Egelman, Vincent P Conticello


Nat. Comm. (2021)

Structural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials

Fengbin Wang, Ordy Gnewou, Charles Modlin, Leticia C Beltran, Chunfu Xu, Zhangli Su, Puneet Juneja, Gevorg Grigoryan, Edward H Egelman, Vincent P Conticello


PNAS (2020)

Structures of filamentous viruses infecting hyperthermophilic archaea explain DNA stabilization in extreme environments

Fengbin Wang, Diana P Baquero, Leticia C Beltran, Zhangli Su, Tomasz Osinski, Weili Zheng, David Prangishvili, Mart Krupovic, Edward H Egelman


Cell Rep. (2020)

Artificial intracellular filaments

Zhaoqianqi Feng, Huaimin Wang, Fengbin Wang, Younghoon Oh, Cristina Berciu, Qiang Cui, Edward H Egelman, Bing Xu


ACS nano. (2020)

Structural determination of a filamentous chaperone to fabricate electronically conductive metalloprotein nanowires

Yun X Chen, Nicole L Ing, Fengbin Wang, Dawei Xu, Nancy B Sloan, Nga T Lam, Daniel L Winter, Edward H Egelman, Allon I Hochbaum, Douglas S Clark, Dominic J Glover


Cell (2019)

Structure of microbial nanowires reveals stacked hemes that transport electrons over micrometers

Fengbin Wang, Yangqi Gu, J Patrick O’Brien, M Yi Sophia, Sibel Ebru Yalcin, Vishok Srikanth, Cong Shen, Dennis Vu, Nicole L Ing, Allon I Hochbaum, Edward H Egelman, Nikhil S Malvankar


Nat. Microbio. (2019)

An extensively glycosylated archaeal pilus survives extreme conditions

Fengbin Wang, Virginija Cvirkaite-Krupovic, Mark AB Kreutzberger, Zhangli Su, Guilherme AP de Oliveira, Tomasz Osinski, Nicholas Sherman, Frank DiMaio, Joseph S Wall, David Prangishvili, Mart Krupovic, Edward H Egelman


PNAS (2019)

A packing for A-form DNA in an icosahedral virus

Fengbin Wang, Ying Liu, Zhangli Su, Tomasz Osinski, Guilherme AP de Oliveira, James F Conway, Stefan Schouten, Mart Krupovic, David Prangishvili, Edward H Egelman


Nat Comm (2017)

A structural model of flagellar filament switching across multiple bacterial species

Fengbin Wang, Andrew M Burrage, Sandra Postel, Reece E Clark, Albina Orlova, Eric J Sundberg, Daniel B Kearns, Edward H Egelman


Structure (2017)

Cryoelectron Microscopy Reconstructions of the Pseudomonas aeruginosa and Neisseria gonorrhoeae Type IV Pili at Sub-nanometer Resolution

Fengbin Wang, Mathieu Coureuil, Tomasz Osinski, Albina Orlova, Tuba Altindal, Gaël Gesbert, Xavier Nassif, Edward H Egelman, Lisa Craig

What we do

Use cryo-EM to understand and design large assemblies

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